UDС 615.282:615.322:582.972.3 THE ANTIFUNGAL ACTIVITY OF LIPOPHILIC FACTIONS OF GALIUM SPECIES. Message 3 N.V.Kashpur, O.V.Goryacha, T.V.Ilyina, A.M.Kovalyova, A.Yu.Volyansky, T.P.Osolodchenko

The antifungal activity of chloroform and ethylacetate ethanolic (8:2) fractions of Lady’s Bedstraw (Galium verum L.), Galium salicifolium Klok. and Cruciform Bedstraw (Galium cruciata (L.) Scop.) in relation to 7 test strains of fungi: Geotriichum candidum (Galactomyces geotrichum) Sklyar 9, Zygosaccharo spp. 40 b/2, Cryptococcus neoformans 32609, Rhodoflorula glutinis F-129, Picha anomala 40, Kluveromyces lactis … Continue reading UDС 615.282:615.322:582.972.3 THE ANTIFUNGAL ACTIVITY OF LIPOPHILIC FACTIONS OF GALIUM SPECIES. Message 3 N.V.Kashpur, O.V.Goryacha, T.V.Ilyina, A.M.Kovalyova, A.Yu.Volyansky, T.P.Osolodchenko

UDС 615.276:582.734.3:581.45 PHYTOCHEMICAL SUBSTANTIATION OF THE ANTI-INFLAMMATORY EFFECT OF BIOLOGICALLY ACTIVE SUBSTANCES OF SORBUS AUCUPARIA LEAVES EXTRACT A.V.Kononenko, S.M.Drogovoz, O.V.Krivoruchko, D.B.Lo­banova

The pharmacological activity of biologically active substances of Sorbus aucuparia has been analysed with the purpose of determination of the prospects for creating anti-inflammatory drugs on its basis.  The current wide range of anti-inflammatory drugs does not solve the problem of the successful treatment of inflammatory diseases and their recurrences, but only generates the need … Continue reading UDС 615.276:582.734.3:581.45 PHYTOCHEMICAL SUBSTANTIATION OF THE ANTI-INFLAMMATORY EFFECT OF BIOLOGICALLY ACTIVE SUBSTANCES OF SORBUS AUCUPARIA LEAVES EXTRACT A.V.Kononenko, S.M.Drogovoz, O.V.Krivoruchko, D.B.Lo­banova

UDC 615.33; 615.28+541.521 THE STUDY OF THE ANTIMICROBIAL ACTIVITY OF OINTMENTS WITH DENSE AND DRY EXTRACTS OF POPLAR CHINESE V.V.Kovalyov, T.G.Yarnykh, V.M.Kovalyov

In order to expand the assortment of national ointments containing substances of the plant origin as active pharmaceutical ingredients the study in determination of the antimicrobial activity of ointments on the hydrophilic and emulsion bases has been carried out. Based on the agar diffusion method the perspectiveness and possibility of developing the technology of soft … Continue reading UDC 615.33; 615.28+541.521 THE STUDY OF THE ANTIMICROBIAL ACTIVITY OF OINTMENTS WITH DENSE AND DRY EXTRACTS OF POPLAR CHINESE V.V.Kovalyov, T.G.Yarnykh, V.M.Kovalyov

UDC 616.36-036.11-099:612.128:547.979-733 THE STATE OF THE GEME METABOLISM IN EXPERIMENTAL DISTURBANCE OF PORPHYRIN EXCHANGE S.I.Kryzhna

The results of change of the activity of enzymes of synthesis (aminolevulinate synthase, aminolevulinic acid dehydratase and hemesyntethase) and decomposition (hemeoxydase) of heme in the liver of rats due to the experimentally disturbed porphyrin metabolism have been presented. The increase in the activity of enzymes of ALA-synthase and ALA-dehydratase has been found, and it led … Continue reading UDC 616.36-036.11-099:612.128:547.979-733 THE STATE OF THE GEME METABOLISM IN EXPERIMENTAL DISTURBANCE OF PORPHYRIN EXCHANGE S.I.Kryzhna

UDC 615.244:615.322:616.36-002:663.252.1 THE EFFECT OF GRAPE SEED EXTRACT ON THE HEPATIC PARENCHYMA OF THE RAT LIVER IN ACUTE CCl4-INDUCED HEPATITIS A.L.Zagayko, S.V.Zaika, O.A.Krasilnikova, Yu.B.Laryanovska

Under the influence of various pathological factors the activation of free radical processes occurs. In case of insufficient capacity of the antioxidant system or its damage, the alternating effects of free radicals, which are a prerequisite for development of many pathological conditions realize. The effect of the grape seed extract on the state of the … Continue reading UDC 615.244:615.322:616.36-002:663.252.1 THE EFFECT OF GRAPE SEED EXTRACT ON THE HEPATIC PARENCHYMA OF THE RAT LIVER IN ACUTE CCl4-INDUCED HEPATITIS A.L.Zagayko, S.V.Zaika, O.A.Krasilnikova, Yu.B.Laryanovska

UDC 615.31:547.03 THE INFLUENCE OF ФNEW METABOLITOTROPIC CARDIOPROTECTOR «LIZINIY» ON THE STATE OF LIMITING LINKS OF THE ENERGY METABOLISM AND COMPENSATORY METABOLIC SHUNTS IN ACUTE MYOCARDIAL INFARCTION I.F.Belenichev, L.I.Kucherenko, I.A.Mazur, N.V.Bukhtiyarova, V.S.Steblyuk, I.V.Pavlyuk, G.V.Georgievsky

Indication of «Liziniy» (2.5% solution for injections, a product of «Pharmatron» RPC) in the dose of 50 mg/kg simultaneously with development of acute myocardial infarction in the experiment results in normalization of the energy metabolism of the heart due to intensification of aerobic reactions and compensatory activation of malate-aspartate shunt, decrease of anaerobic glycolysis and … Continue reading UDC 615.31:547.03 THE INFLUENCE OF ФNEW METABOLITOTROPIC CARDIOPROTECTOR «LIZINIY» ON THE STATE OF LIMITING LINKS OF THE ENERGY METABOLISM AND COMPENSATORY METABOLIC SHUNTS IN ACUTE MYOCARDIAL INFARCTION I.F.Belenichev, L.I.Kucherenko, I.A.Mazur, N.V.Bukhtiyarova, V.S.Steblyuk, I.V.Pavlyuk, G.V.Georgievsky

UDС 615.454.1:618.15-002 RESEARCH OF A NEW COMBINED VAGINAL CREAM FOR TREATING NON-SPECIFIC VAGINITIS S.M.Drogovoz, G.V.Zaychenko, O.V.Grishchenko, O.S.Busygіn, K.V.Drogovoz

Among the infectious-inflammatory diseases of the genital tract, which are the actual problem in modern gynecology, the most common ones are vulvovaginal candidiasis, non-specific vaginitis and bacterial vaginosis. The analysis of the pharmaceutical market of Ukraine has shown the lack in the assortment of the domestic medicines with antifungal and antibacterial properties. Klivazol is the … Continue reading UDС 615.454.1:618.15-002 RESEARCH OF A NEW COMBINED VAGINAL CREAM FOR TREATING NON-SPECIFIC VAGINITIS S.M.Drogovoz, G.V.Zaychenko, O.V.Grishchenko, O.S.Busygіn, K.V.Drogovoz

UDC 615.065:547.728.54.061/062]001.8 DIAGNOSTICS OF MORTAL SULPIRIDE POISONINGS BY THE RESULTS OF TOXICOLOGICAL EXAMINATIONS S.V.Bayurka, V.V.Bolotov, S.A.Karpushina, V.I.Stepanenko, G.I.Severina

Efficiency of the isolation method of medicinal substances in relation to sulpiride by its elution with chloroform from the biological tissue homogenized by grinding with anhydrous sodium sulphate has been determined. The method allowed to separate 14.1±1.9% of the medicinal substance. Sulpiride was detected in the biological extracts with the help of the colour reactions, … Continue reading UDC 615.065:547.728.54.061/062]001.8 DIAGNOSTICS OF MORTAL SULPIRIDE POISONINGS BY THE RESULTS OF TOXICOLOGICAL EXAMINATIONS S.V.Bayurka, V.V.Bolotov, S.A.Karpushina, V.I.Stepanenko, G.I.Severina

UDC 616.127-005.8-008.61[65-07:577.112]-08:615.22.015.3 THE DOSE-DEPENDENT INFLUENCE OF ATORVASTATIN TAKEN IN RANGED DOSES IN RELATION TO CIRCULATING BIOMECHANICAL STRESS MARKERS IN PATIENTS WITH Q-WAVE MYOCARDIAL INFARCTION. RESULTS OF 1-YEAR COHORT STUDY O.Ye.Berezin, T.O.Samura

54 patients with Q-wave myocardial infarction (42 male, 77.8%) were enrolled to the study. During 72 hours after Q-wave myocardial infarction documentation all subjects were immediately dispensed into two groups, 27 persons in each depending on a daily dose of atorvastatin. The patients of the first group were taken a conventionally high dose and the … Continue reading UDC 616.127-005.8-008.61[65-07:577.112]-08:615.22.015.3 THE DOSE-DEPENDENT INFLUENCE OF ATORVASTATIN TAKEN IN RANGED DOSES IN RELATION TO CIRCULATING BIOMECHANICAL STRESS MARKERS IN PATIENTS WITH Q-WAVE MYOCARDIAL INFARCTION. RESULTS OF 1-YEAR COHORT STUDY O.Ye.Berezin, T.O.Samura