Month: January 2013

The results of experimental studies on puberal male rats in studying chronopharmacological peculiarities of mildronate influence («Grindex» JSC, Latvia) on the indices of the excretory renal function have been described. Mildronate (50 mg/kg) was injected intraperitoneally in different periods of Read more

Despite the great number of anti-inflammatory drugs, the problem of the effective and safe therapy of rheumatic diseases has not yet been solved. That is why the continuous search for new treatments and drugs with the non-traditional mechanism of action Read more

On the forced stencil wound model in rats the effectiveness of a new combined wound healing ointment «Prolіdoxyd» containing phenolic hydrophobic propolis medicine and lidocaine has been studied. The reparative ointment of the natural origin «Wundahyl», which is used in Read more

In the course of investigation the NO-depended mechanisms of MT cardioprotective effect in myocardial infarction have been studied. It has been found that MT intraperitoneal introduction (the product of Scientific Production Association «Pharmatron», Ltd.) in the dose of 2.5 mg/kg Read more

The hypolipidemic activity of some derivatives of 3-methylxanthines has been studied. A number of compounds that change the levels of cholesterol, triacylglycerols and β-lipoproteids in the rat blood serum has been revealed in the experimental hyperlipidemy from groups 8-N-alkylamine derivatives Read more

The pharmacological studies of the prostate-protective action of suppositories based on the raw material for treatment of prostate gland diseases has been carried out. To reproduce prostatitis the model of cryotraumatic damage in the prostate gland has been used. The Read more

The cardioprotective action of the combination of quercetine with the derivatives of glucosamine has been studied in the comparative aspect with its active monocomponents – the mixture of aminosugars and quercetine – on the model of doxorubicine cardiomyopathy in rats. Read more

The results of clinical and economic analysis of the chronical heart failure (ChHF) pharmacotherapy in the medical preventive institution are given. АВС-, VEN- and frequency analyses have been used. It has been found that pharmacotherapy of ChHF is mainly conducted Read more

Interleukin-4 (IL-4) is involved in the regulation of various functions of B cells, T cells, macrophages, and other hematopoietic and nonhematopoietic cells. IL-4 gene is expressed in two mRNA forms: 1) full-length form containing all four exons and 2) alternatively Read more

The need for determining the influence of non-therapeutic factors on clinical parameters used in practically every clinical trial to estimate the patient’s/volunteer’s state, as well as the variables of tolerability and effectiveness, has been found. In order to ensure the Read more