MODELING OF MEASUREMENT PROCESSES IN CLINICAL DRUG TRIALS
This paper discusses the features of measurement in clinical trials. The factors that affect the measured parameters in the laboratory and clinical conditions have been analyzed. The measurement model in clinical trials taking into account the non-therapeutic factors impact has been proposed. The causes and sources of uncertainty arising from the measurement of the criteria for evaluation of the new drugs properties have been identified and classified. It is found that the difficulties in formalizing criteria as measured values in CT lead to uncertainty which is associated with the inadequacy of measurement models in the evaluation process developed by new medicine. The restriction of non-therapeutic factors, inadequate consolidation of their actions by the including in the sub-groups, as well as limiting their actions in time, should cause uncertainty of a specification. In the assessments of CT uncertainties should take into account the difficulties of repeating of the multiple observations for the same patient. The proposed approaches to modeling of measurement can be used in the planning stages of experimental clinical trials of studied drugs. Considered in this paper, the measurement model in CI drugs can be further refined and detailed depending on the nature of the research. Key words: measurement uncertainty, clinical trials, measurement model, impact factors.
О. О. Tarasenko
THE ANALYSIS OF STUDENTS’ KNOWLEDGE AND SKILLS CONTROL QUALITY AS ILLUSTRATED BY THE EXAMPLE OF THE SUBJECT «CLINICAL STUDY OF PHARMACEUTICALS»
Teacher’s task during students’ knowledge and skills control quality is in revealing of the real level of knowledge in the process of knowledge evaluation control, thus helping the students to organize their further educational work in an effective way. At the present stage the search of ways of students’ learning progress evaluation with due respect to control basic functions is still of great importance. On the basis of foreign and domestic approaches to students’ progress evaluation in the conditions of credit-unit system there were developed the criteria of effective control of students’ knowledge and skills: consistency, objectivity, comprehensiveness, individuality, adequateness, transparency. The analysis of control quality of students’ knowledge and skills at acquirement of the subject «Clinical Study of Pharmaceutical» due to specified criteria demonstrated that the control system functions only partially. This is stipulated with insufficient level of assessment of students in-class work, solitary work and individual work; with insufficient level of using the test forms for final knowledge check; with low level of individual and differential approaches to evaluation of students’ study activities; low level of implementation of evaluation interactive forms and methods. Thus, in order to improve the efficiency of students’ knowledge and skills control it is necessary to develop and to implement the system of students’ knowledge and skills control along with development of algorithm of conducted work efficiency analysis. Key words: study activities control, assessment quality, conditions of improvement of study activities control quality
О. О. Andrieieva
RESEARCH OF MOTIVATION TO PROFESSION OF PHARMACIST AMONG STUDENTS OF NATIONAL UNIVERSITY OF PHARMACY DURING IMPROVEMENT THE COURSE “CLINICAL PHARMACY” TEACHING
The paper considers the issues of modern pharmaceutical education depended not only on content but on the way and the form in which learning material is presented by reproductive | and innovative teaching methods. This becomes the cause for reviewing of approaches !…. to methodology of courses teaching in higher pharmacy school. By example of binary j lection implementation into the pedagogical process there was analyzed positive impact on | students’ attitude to their future profession. Key words: professional motivation, binary lection, diagnostics.
Е. N. Evtushenko, Osama Abuzaid Mohamed Nour Ahmed
BASIC DEVELOPMENT DIRECTIONS OF ADVANCE OF PHARMACEUTICAL SECTOR OF SUDAN
The medicines provision system in Sudan has been analyzed, issues similar to the Ukrainian issues have been observed. The most important issue among the designated issues is decentralized management of procurement and delivery of medicines. The reasonability of choice of the priority-oriented direction of advance of pharmaceutical sector structure, which is centralization of the medicines provision system has been proved. It has been demonstrated that one of reorganizing measures should become integration of systems of procurement and distribution of two state establishments – a wholesale pharmaceutical establishment the Medical Provision Center and current fund of medicines. As it has been identified during of the research, their functions are currently duplicated to a large extent. The implementation of the proposed measures will allow significantly improve the organization of procurement and distribution of medicines, increase their physical and economical availability, achieve significant economy of the state funds. The obtained results will have been used during the further research on scientific and methodic background of development directions and management of the pharmaceutical market issues of Sudan. Key words: Sudan, pharmacy, medicines, distribution, state provision.
УДК 339.13:615.212.7 (477)
М. N. Kobets
ANALYSIS OF DRUGS CONTAINING CONTROLLED SUBSTANCES SALES IN UKRAINIAN PHARMACEUTICAL MARKET
Both a problem of drug addicts treatment and rehabilitation and a problem of patients supply with drugs containing controlled substances, which are necessary for medical purposes, as well as a problem of these drugs runoff prevention from the scope of legal exchange to illegal one exist nowdays in Ukraine. This outlined a relevance of research on the analysis of the dynamics of drugs containing controlled substances market volume and its level of monopolization examination. As of March 3, 2014, 80 drugs containing controlled substances trade names are registered in Ukraine. It was found, that foreign producers (54.4 %) possess drugs containing controlled substances market leadership. The largest number of drugs containing controlled substances items are imported to Ukraine from India – 15.3 % of the total range of drugs containing controlled substances. Leading preparations were assessed in terms of sales in physical and monetary terms between 2011 to 2013 (Ql). The first place in terms of sales in terms of quantity takes a domestic product Kodterpin 1С®, tablets, No. 10 in blister, open corporation “InterHim” (Ukraine, Odessa), with sales for 2012 14,233,023 packs exceeding the mentioned rate per 128 % compared to sales in 2011. Herfindahl-Hirschman Index was calculated for studying the level of monopolization. It was found that the drug market for this group possesses a monopoly. Key words: marketing research, drugs containing controlled substances, consumption, sales, monopolization of the market.
THE MODERN CONCEPT OF PHARMACEUTICAL MARKETING: HOLISTIC APPROACH
The main types of marketing by the structure of marketing concepts have been detailed, scientific views regarding disclosure of the category ‘holistic marketing’ and the constituent elements of the concept have been systematized. The existing approaches to the construction of the structural model holistic marketing and adapting it to the business of the pharmaceutical industry have been researched. The author’s vision of the modern model holistic marketing in pharmacy has been posted and proved. Key words: marketing, marketing concept, holistic marketing, pharmaceutical marketing, pharmacy.
S. Nemchenko, L. I. Fursa
National University of Pharmacy, Kharkiv
STUDY OF SOCIO-EPIDEMIOLOGICAL INDICATORS OF MALIGNANT NEOPLASMS OF THE TRACHEA, BRONCHUS AND LUNG IN UKRAINE
The results of research on the socio-epidemiological morbidity and mortality of malignant neoplasm of trachea, bronchus and lung in Ukraine as a whole and in the regions have been presented in Ukraine. The study was conducted for the period of 2007-2012 years according to the National Cancer Registry of Ukraine. It have been established that morbidity and mortality of the nosology retains a tendency to decrease among men and increasing among women. The highest incidence observed in Kirovohrad, Mykolaiv, Zaporizhia regions, the lowest – in Volyn, Rivne, Zhytomyr, Ivano-Frankivsk and others. Results of the study is a scientific justification of the priorities of cancer struggle in Ukraine on the basis of dynamic and territorial characteristics of epidemiological development. Key words: malignant neoplasm of trachea, bronchus and lung; morbidity and mortality.
THE RESEARCH RESULTS INDICATOR «THRESHOLD WILLINGNESS TO PAY» IN THE HEALTH SYSTEM AND PHARMACEUTICAL PROVIDING OF POPULATION OF UKRAINE
The article presents the results of investigations of the indicator «threshold willingness to pay» in Ukraine. The indicator defines the limit of the cost-effectiveness of the state and society on the organization of effective medical and pharmaceutical care to the population at a level that ensures the lives of patients. Calculated and analyzed for the first time in years, the dynamics of indicators of «threshold willingness to pay» in the national health care and pharmaceutical provision of population. It was established that the average value of the «threshold of willingness to pay» in Ukraine in 7,3 less than in the United States, as well as 3,5, 2,7 and 1,9 times less then compared with a similar parameter in the Russian Federation, Kazakhstan and Azerbaijan respectively. During the period of 2009-2013 value of the indicator «threshold willingness to pay» increased and characterized the complex dynamics of change. The problem of increasing the level of threshold willingness to pay for the state and society in Ukraine saving the lives of citizens, as well as the introduction of innovative medical technologies should be addressed systematically on a range of directions. One of these directions is the introduction of socially adapted financing mechanisms for the health care system, which function in models of compulsory health insurance. Key words: innovative medical technologists, threshold of willingness to pay, threshold of фармакоэкономической expediency, pharmacoeconomic analysis.
UDC: 615.1: 615.03
M. V. PODGAINA
National University of Pharmacy, Kharkov
RESULTS OF RETROSPECTIVE ANALYSIS OF REGISTRATION OF ANTITUBERCULOSIS DRUGS AND THEIR PRESENCE IN STATE FORMULARY LIST IN UKRAINE
The results of a retrospective analysis of the domestic pharmaceutical market of antituberculiosis drugs are present in the article. Particular structural assessment of specified segment of the pharmaceutical market by the total quantity taking into account features of tuberculiosis therapy (drugs of the I and II ranges) in the dynamics of years and by the parameter “domestic / imported” had carried out. The author also presents the results of the study of antituberculiosis drugs available in five issues of the State Formulary List (for 2009-2013) and gives calculated share of domestic drugs in the general structure of antituberculiosis drugs listed in State Formulary List depending on the line therapy. Key words: pharmaceutical market, antituberculosis drugs, registration of drugs, formulary list, retrospective analysis.