Journal ”Management, Economics and Quality Assurance in Pharmacy” №6 (32) 2013

FULL TEXT

L. N. Andryukova, E. G. Fetisova, O. N. Yakubchuk, S. N. Kovalenko
IDENTIFICATION OF CRITICAL QUALITY ATTRIBUTE FOR EYE DROPS MEDICINAL FORM
A common set of quality attribute and criteria of their acceptability, as well as critical quality attribute that are the basis for the development of target quality profile of eye drops with a particular pharmacological action and for identify potential quality attribute have been defined for eye drops dosage form

Key words: quality, critical quality attribute, pharmaceutical development, eye drops, knowledge management

G. I. Borshchevskii, I. V. Komarov, A. V. Kulinich
FACTORS WHICH INFLUENCE LESFAL SAMPLES STABILITY
Visible light absorption spectroscopy and fluorescent spectroscopy was used to show that in some cases degradation of the minor component of the formula – riboflavin – might occur in therapeutic drug Lesfal during studies of its stress stability. Measurements of physicalchemical characteristics, in particular, pH and molecular oxygen concentration allowed to conclude that the degradation is due to the excess of molecular oxygen in solutions.

Key words: hepatotropic therapeutics, phosphatidylcholine, fluorescent spectroscopy, oxidative degradation.

S. I. Merzlikin, V. Moskalenko
DEVELOPMENT AND STANDADISATION OF ANALYTICAL DIAGNOSTIC CONDITIONS OF ACUTE POISONING WITH METFORMIN
This article presents the solution of the scientific problem, relating to conditions of the development of acute metformin poisoning analytical diagnostics. It was synthesized the metformin derivative – triacetyl-1,1-dimetilbiguanid as a marker of analytical diagnostic, studied its physical-chemical properties, methods of NMR- and UV-spectroscopy were used for determination its structure. Conditions of isolation of metformin derivative from the model urine sample developed and standardized, and also of chromatographic determination in obtained extracts.

Key words: metformin, acute poisoning, forensic research, identification, TLC, UVspectroscopy.

V. I. Gorodetskaya, V. A. Lebedynets, S. N. Kovalenko
RESEARCH OF PHARMACEUTICAL LABOUR MARKET IN QUALITY MANAGEMENT
In order to determine the feasibility of developing and implementing the system of higher pharmaceutical education professional training in quality management for the pharmaceutical sector in health care, we have carried out research work in the pharmaceutical market of Ukraine. Based on the data were calculated indices supply and demand in that segment of the labor market, analyzed the prevalence of pharmaceutical shortages of existing staff by region of Ukraine, by the requirements of employers in education and experience requirements for quality management, as well as the overall level of applicants for this position.

Key words: pharmaceutical job market, experts in managing qualitative bye, Department of Quality Management qualification in the field of quality management.

L. Iakovlieva, O. Tkachоva
PHARMACOECONOMIC ANALYSIS «COST-EFFECTIVENESS» IN THE TREATMENT OF THREATENED ABORTION RESUME
Was carried a comparative pharmacoeconomic evaluation of two drug regimens using the progestagenic preparations that are progesterone hormone analogues: hydroxyprogesterone («Оxyprogesteroni caproate» Pharmak, Ukraine) and dydrogesterone («Duphaston», Abbott Lab., The Netherlands). The number of stored pregnancies after a course of treatment progestagen drugs as a criterion of effectiveness were treated. According to the analysis of the «cost-effectiveness» pharmacotherapy of pregnant drug «Duphaston» has a higher efficiency at a lower value cost per treated pregnant, which allows to consider the drug more cost-effective in the treatment of threatened abortion.

Key words: pharmacoeconomiс analysis, treatment of threatened abortion, progestogen preparations.

K. A. Lyuhanova
ANALYSIS OF SALES VOLUMES OF ANTITHROMBOTIC MEDICINES ON UKRAINIAN PHARMACEUTICAL MARKET
Have been analyzed the market of antithrombotic medicines. It was determined that the leading position belongs to foreign manufacturers. Established the sales of products in natural and in money terms from the total sales volume of imported medicines of antithrombotic action. Calculated the coefficients of competitiveness of antithrombotic medicines and established the level of tension between the producers.

Key words: antithrombotic medicines, coefficient of competitiveness, level of tension.

A.S. Nemchenko, K.L. Kosyachenko
PHARMACOECONOMIC EVALUATION OF AGONISTS OF GONADOTROPINRELEASING HORMONE IN PROSTATE CANCER THERAPY
There are results of pharmacoeconomic evaluation of hormone therapy for prostate cancer. The authors analyze current treatment protocols and State form of drugs on approaches to the treatment of prostate cancer in Ukraine. Found that prostate cancer therapy involves the use of analogues of gonadotropin-releasing hormone, namely goserelin, leuprolide and triptorelin. The choices of drugs with the sense of minimizing costs, and calculate the possible amount of savings for the entire population of prostate cancer patients in Ukraine in the case of the least expensive technology. To study the results of randomized clinical trials on the efficacy of goserelin, leuprolide and triptorelin for the treatment of prostate cancer allowed determining the optimal drugs from the group analogues of gonadotropin – releasing hormone in terms of «cost – effectiveness».

Key words: pharmacoeconomic evaluation of prostate cancer, analogs of gonadotropinreleasing hormone, goserelin, leuprorelin, triptorelin.