UDС 615.276:582.734.3:581.45 PHYTOCHEMICAL SUBSTANTIATION OF THE ANTI-INFLAMMATORY EFFECT OF BIOLOGICALLY ACTIVE SUBSTANCES OF SORBUS AUCUPARIA LEAVES EXTRACT A.V.Kononenko, S.M.Drogovoz, O.V.Krivoruchko, D.B.Lo­banova

The pharmacological activity of biologically active substances of Sorbus aucuparia has been analysed with the purpose of determination of the prospects for creating anti-inflammatory drugs on its basis.  The current wide range of anti-inflammatory drugs does not solve the problem of the successful treatment of inflammatory diseases and their recurrences, but only generates the need for searching alternative drugs with the anti-inflammatory effect for effective and safe treatment. The study of new anti-inflammatory agents is conducted taking into account the etiology, pathogenesis and clinical manifestations of inflammatory diseases. Thus, biologically active substances of Sorbus aucuparia fruits and leaves can influence on infectious, toxicological and radiological factors, different stages of inflammation – alteration, exudation and proliferation (phenolic compounds are the main group that is responsible for the pathogenic mechanisms), as well as reduce edema, decrease temperature and relieve the pain.

Key words: biologically active substances of Sorbus aucuparia, anti-inflammatory effect, phenolic compounds