UDC 615.33; 615.28+541.521 THE STUDY OF THE ANTIMICROBIAL ACTIVITY OF OINTMENTS WITH DENSE AND DRY EXTRACTS OF POPLAR CHINESE V.V.Kovalyov, T.G.Yarnykh, V.M.Kovalyov

In order to expand the assortment of national ointments containing substances of the plant origin as active pharmaceutical ingredients the study in determination of the antimicrobial activity of ointments on the hydrophilic and emulsion bases has been carried out. Based on the agar diffusion method the perspectiveness and possibility of developing the technology of soft medicinal forms containing dense (hydrophobic fraction) and dry (hydrophilic fraction) extracts of Chinese poplar for treating infectious complications of wounds have been experimentally studied and proven. Study of antimicrobial activity dependence of the ointment base components was carried out. The results of these studies have shown that the experimental samples of ointments revealed a pronounced antimicrobial action against strains of S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulg. The dependence of the antimicrobial activityof the ointment base components have been studied. Advantages of using the hydrophilic ointment base have been proven.

Key words: ointment, extract of poplar, ointment base, purulent-inflammatory process