The aim of the research was to develop an experimental model of intestinal dysbiosis induced by diclofenac sodium and to study the effect of probiotic Bifidumbacterin on functional characteristics of the intestine in the reproducible conditions. Animals were divided into 2 groups of 10 animals in each group. The group of control pathology received daily 20 mg/kg of diclofenac sodium intragastrically for 20 days. Confirmation of gastrointestinal dysbiosis reproduced on clinical sings was general aggravation of the clinical state and development of gastropathies. Efficiency in the reproduction of intestinal dysbiosis was confirmed by registration of directed changes in the original structure of the experimental animals’microflora. Treatment of guinean pigs with dysbiosis was conducted orally by bifidumbacterin twice a day; the single volume was 1 ml containing 107 microbes of viable bifidobacteria. The positive therapeutic effect of probiotic therapy was 20%.
Key words: dysbiosis, guinean pigs, model, diclofenac sodium, bifidumbacterin