The cardioprotective activity of a new compound has been studied on the myocardial infarction (MI) model by the method of diathermy coagulation of the coronary artery marginal branch. The study was conducted on male outbred albino rats with the weight of 200-220 g. Compound 77 was introduced in the effective dose of 5 mg/kg, the reference medicine (Mexidol by Pharmasoft, Russia) was injected in the dose of 100 mg/kg. It has been established that spirocyclic oxindolic derivative in the dose of 5 mg/kg reveals the cardioprotective effect at the mexidol level in the dose of 100 mg/kg. the integral cardioprotective effect of the compound studied on the diathermocoagulation model of acute cardiac ischemia is characterized by significant descrease of the lethality index during the critical period of the experiment (the 12 hour of developing MI). Compound 77 and Mexidol reliably reduce the mortality rate in rats by 40%. It has been established that according to the ECG data the spirocyclic oxindolic derivativе reveals the same protective effect on the heart as mexidol.
Key words: spirocyclic oxindolic derivativе, cardioprotection
