The research results of the influence of thick extract of Silver birch leaves in the dose of 7 mg/kg and the reference medicine “Canephron® N” in the dose of 20 mg/kg on the functional activity of the kidneys, as well as on the histological structure of the kidneys under conditions of diabetic nephropathy in rats developing during 3 months in the conditions of the experimental diabetes induced by Alloxan in the dose of 200 mg/kg are represented. As a result of the long-term pathology development the renal dysfunctions and initial signs of intercapillary glomerulosclerosis were observed in rats. The thick extract of Silver birch leaves improved the functional state of the kidneys by decreasing proteinuria and glycosuria, as well as had a positive effect on the reduction of the structural damage of the kidneys, exceeding significantly the healing effect of the reference medicine “Canephron® N”. Thus, the thick extract of Silver birch leaves is a perspective substance for creating a medicine for the treatment of diabetic nephropathy.
Key words: thick extract of Silver birch leaves; diabetic nephropathy; functional state of the kidneys; structural damage of the kidneys