UDC 615.065:547.728.54.061/062]001.8 DIAGNOSTICS OF MORTAL SULPIRIDE POISONINGS BY THE RESULTS OF TOXICOLOGICAL EXAMINATIONS S.V.Bayurka, V.V.Bolotov, S.A.Karpushina, V.I.Stepanenko, G.I.Severina

Jan 29

UDC 615.065:547.728.54.061/062]001.8 DIAGNOSTICS OF MORTAL SULPIRIDE POISONINGS BY THE RESULTS OF TOXICOLOGICAL EXAMINATIONS S.V.Bayurka, V.V.Bolotov, S.A.Karpushina, V.I.Stepanenko, G.I.Severina

Efficiency of the isolation method of medicinal substances in relation to sulpiride by its elution with chloroform from the biological tissue homogenized by grinding with anhydrous sodium sulphate has been determined. The method allowed to separate 14.1±1.9% of the medicinal Read more

Jan 29

UDC 616.127-005.8-008.61[65-07:577.112]-08:615.22.015.3 THE DOSE-DEPENDENT INFLUENCE OF ATORVASTATIN TAKEN IN RANGED DOSES IN RELATION TO CIRCULATING BIOMECHANICAL STRESS MARKERS IN PATIENTS WITH Q-WAVE MYOCARDIAL INFARCTION. RESULTS OF 1-YEAR COHORT STUDY O.Ye.Berezin, T.O.Samura

54 patients with Q-wave myocardial infarction (42 male, 77.8%) were enrolled to the study. During 72 hours after Q-wave myocardial infarction documentation all subjects were immediately dispensed into two groups, 27 persons in each depending on a daily dose of Read more

Jan 29

UDC 661.12:658.562:615.07 DEVELOPMENT OF METHODS OF TOLERABILITY ASSESSMENT FOR STUDYING DRUG BIOEQUIVALENCE V.Ye.Dobrova

This method for evaluation of tolerability when studying drug bioequivalence has been proposed. While its developing a generalized block diagram for carrying out the research in accordance with the requirements of ICH GCP and the algorithm of statistical planning and Read more

Jan 29

UDC 615.2:615.011].001.57:004.382 IN SILICO: THE NEW FIELD IN DEVELOPMENT OF PHARMACOLOGICAL AND PHARMACEUTICAL PROPERTIES OF MEDICINES I.S.Chekman, T.Yu.Nebesna, P.V.Simonov

This article deals with the analysis of literature and research results in the field of in silico technologies. The information of the main in silico methods is summarized. The main principles of molecular docking, homology modelling method, virtual screening, pharmacophore Read more

Jan 25

On January 25, on the day of St. Tatiana the parade of nerds took place

On January 25, on the day of St. Tatiana – the patroness of all students -THE PARADE OF NERDS took place. This first and unique event which marks the beginning of a new city tradition was held in the renovated Read more

Jan 25

January 25, 2013 Specialized Academic Council Meeting D 64.605.03.

Ph.D. Dissertations Defense: Korovenkova O.M. (Scientific supervisor D.M., prof. Kosuba R.B.) Kurt-Ahmetova G.S. (Scientific supervisor D.M., prof. Mamchur V.I.) Responsible Chairman of the Specialized Scientific Council prof. Zupanets I.A. Academic Secretary of the Specialized Scientific Council assoc. prof. Saharova Read more

Jan 24

UDC 615.065:547.728.54.061/062]001.8 DIAGNOSTICS OF MORTAL MIANSERIN POISONINGS BY THE RESULTS OF TOXICOLOGICAL RESEARCH S.V.Bayurka, S.A.Karpushina

It has been determined that isolation of mianserin from the biological material by acidified acetonitrile (according to I.Szrzedzinski’s method) is more effective for forensic and toxicological examination than isolation by neutral acetone (by V.A.Kartashov’s method) and chloroform. Resolution of the Read more

Jan 24

UDC 616.6:616.379:615.25:615.322 THE NEPHROPROTECTIVE EFFECT OF THICK EXTRACT OF SILVER BIRCH LEAVES IN THE EXPERIMENTAL DIABETIC NEPHROPATHY IN RATS N.S.Chorna, Yu.B.Laryanovska, О.М.Gorban, Т.К.Yudkevich, D.M.Babenko

The research results of the influence of thick extract of Silver birch leaves in the dose of 7 mg/kg and the reference medicine “Canephron® N” in the dose of 20 mg/kg on the functional activity of the kidneys, as well Read more

Jan 24

UDC 615.011:547.857.4 PHARMACOLOGICAL SCREENING OF 3-SUCCINYLSUBSTITUTED N-PHENYLANTHRANILIC ACIDS М.М.Suleyman, S.G.Isaev, А.M.Semenov, T.S.Sakharova, M.V.Zupanets

In the process of pharmacological screening of 3-succinylsubstituted N-phenylanthranilic acids it has been found that these compounds show a high anti-inflammatory, analgetic, diuretic, fungistatic and bacteriostatic activity. The parameters of acute toxicity have been defined for the most active derivatives, Read more

Jan 24

UDC 615.33:616.34 EXPERIMENTAL MODELING OF INTESTINAL DYSBIOSIS INDUCED BY DICLOFENAC SODIUM IN GUINEAN PIGS AND THE INFLUENCE OF BIFIDUMBACTERIN ON FUNCTIONAL CHARACTERISTICS OF THE INTESTINE IN THE REPRODUCIBLE CONDITIONS N.I.Filimonova, V.O.Pasisnychenko, Mohamed Moftah Elati, S.V.Misyureva

The aim of the research was to develop an experimental model of intestinal dysbiosis induced by diclofenac sodium and to study the effect of probiotic Bifidumbacterin on functional characteristics of the intestine in the reproducible conditions. Animals were divided into Read more