This article presents the results of the influence of the spirocyclic oxindolic derivative in the dose of 5 mg/kg on the cerebral energy metabolism of experimental pathology with hypoxic and nonhypoxic genesis. It has been found that a new compound Read more
The screening investigation of the anticonvulsant activity of dry extracts from 8 species of plants of the families of Solanaceae, Papaveraceae, Lamiaceae and Polemoniaceae on the model of corazol-induced seizures in mice has been carried out. By the research results Read more
The influence of Flarosuccin syrup in comparison with Phytolysin paste on the indexes of electrolyte metabolism in rats (the content of calcium and phosphorus in the blood and their excretion with urine) has been studied. It has been determined that Read more
Resolution of the generally accepted in forensic and toxicological analysis isolation methods of drugs has been studied with regard to sulpiride by the methods of O.O.Vasilyeva, Stas-Otto, V.Ph.Kramarenko, which allowed to isolate 8.6±1.4%, 18.3±1.8%, 4.9±0.7% of the antidepressant researched, respectively. Read more
The work is dedicated to the study of peculiarities of 14C-ethoxozepam pharmacokinetics and metabolism in mice after intravenous administration. 14С-ethoxozepam readily distributes in the organs and tissues, in a high concentrations it is determined in the adipose tissue and penetrates Read more
The effective direction of solving modern problems of prescription dispensing violation of medicines and uncontrolled self-treatment should become the introduction of experience of technologies of computer-integrated electronic medical cards and electronic prescriptions to the domestic health system. intercompatibility of healthcare Read more
It has been proven that recently Ukraine is one of the key venues for clinical research by international pharmaceutical companies. This fact has formed the demand for quality logistics and clinical relevance of the study resulted in the assessment of Read more
Arterial hypertension is revealed in 25–30% of the adult population of the economically developed countries, including Ukraine. In the last 10-15 years there is a high interest to metabolic disorders in arterial hypertension. By estimations of most experts insulin resistance Read more
The importance of gene polymorphisms in the system of drug biotransformation in efficacy and safety, as well as in manifestation of many pathological processes is shown in numerous papers. A set of activities, including the building of individual genetic maps, Read more
The effective methods of liquid-liquid extraction of sulpiride from the biological fluids with ethyl acetate from the alkaline medium at pH 10-11 have been developed. Identification of sulpiride in the biological extracts obtained was carried out by the Marquis test Read more
