UDC 661.12:658.562:615.07 DEVELOPMENT OF METHODS OF TOLERABILITY ASSESSMENT FOR STUDYING DRUG BIOEQUIVALENCE V.Ye.Dobrova

This method for evaluation of tolerability when studying drug bioequivalence has been proposed. While its developing a generalized block diagram for carrying out the research in accordance with the requirements of ICH GCP and the algorithm of statistical planning and evaluation of tolerability/safety have been proven. The peculiarities and implementation possibilities of this algorithm have … Continue reading UDC 661.12:658.562:615.07 DEVELOPMENT OF METHODS OF TOLERABILITY ASSESSMENT FOR STUDYING DRUG BIOEQUIVALENCE V.Ye.Dobrova

UDC 615.2:615.011].001.57:004.382 IN SILICO: THE NEW FIELD IN DEVELOPMENT OF PHARMACOLOGICAL AND PHARMACEUTICAL PROPERTIES OF MEDICINES I.S.Chekman, T.Yu.Nebesna, P.V.Simonov

This article deals with the analysis of literature and research results in the field of in silico technologies. The information of the main in silico methods is summarized. The main principles of molecular docking, homology modelling method, virtual screening, pharmacophore modelling and QSAR have been examined. The attention is paid to the use of in … Continue reading UDC 615.2:615.011].001.57:004.382 IN SILICO: THE NEW FIELD IN DEVELOPMENT OF PHARMACOLOGICAL AND PHARMACEUTICAL PROPERTIES OF MEDICINES I.S.Chekman, T.Yu.Nebesna, P.V.Simonov

January 25, 2013 Specialized Academic Council Meeting D 64.605.03.

  Ph.D. Dissertations Defense: Korovenkova O.M. (Scientific supervisor D.M., prof. Kosuba R.B.) Kurt-Ahmetova G.S. (Scientific supervisor D.M., prof. Mamchur V.I.) Responsible Chairman of the Specialized Scientific Council prof. Zupanets I.A. Academic Secretary of the Specialized Scientific Council assoc. prof. Saharova T.S.

UDC 615.065:547.728.54.061/062]001.8 DIAGNOSTICS OF MORTAL MIANSERIN POISONINGS BY THE RESULTS OF TOXICOLOGICAL RESEARCH S.V.Bayurka, S.A.Karpushina

It has been determined that isolation of mianserin from the biological material by acidified acetonitrile (according to I.Szrzedzinski’s method) is more effective for forensic and toxicological examination than isolation by neutral acetone (by V.A.Kartashov’s method) and chloroform. Resolution of the methods in relation to mianserin was 24.8±2.4%, 11.3±1.0% and 17.7±1.5%, respectively. Detection of mianserin isolated … Continue reading UDC 615.065:547.728.54.061/062]001.8 DIAGNOSTICS OF MORTAL MIANSERIN POISONINGS BY THE RESULTS OF TOXICOLOGICAL RESEARCH S.V.Bayurka, S.A.Karpushina

UDC 616.6:616.379:615.25:615.322 THE NEPHROPROTECTIVE EFFECT OF THICK EXTRACT OF SILVER BIRCH LEAVES IN THE EXPERIMENTAL DIABETIC NEPHROPATHY IN RATS N.S.Chorna, Yu.B.Laryanovska, О.М.Gorban, Т.К.Yudke­vich, D.M.Babenko

The research results of the influence of thick extract of Silver birch leaves in the dose of 7 mg/kg and the reference medicine “Canephron® N” in the dose of 20 mg/kg on the functional activity of the kidneys, as well as on the histological structure of the kidneys under conditions of diabetic nephropathy in rats … Continue reading UDC 616.6:616.379:615.25:615.322 THE NEPHROPROTECTIVE EFFECT OF THICK EXTRACT OF SILVER BIRCH LEAVES IN THE EXPERIMENTAL DIABETIC NEPHROPATHY IN RATS N.S.Chorna, Yu.B.Laryanovska, О.М.Gorban, Т.К.Yudke­vich, D.M.Babenko

UDC 615.011:547.857.4 PHARMACOLOGICAL SCREENING OF 3-SUCCINYLSUBSTITUTED N-PHENYLANTHRANILIC ACIDS М.М.Suleyman, S.G.Isaev, А.M.Semenov, T.S.Sakharova, M.V.Zupanets

In the process of pharmacological screening of 3-succinylsubstituted N-phenylanthranilic acids it has been found that these compounds show a high anti-inflammatory, analgetic, diuretic, fungistatic and bacteriostatic activity. The parameters of acute toxicity have been defined for the most active derivatives, it gave an opportunity to classify them as low-toxic substances during the intragastric injection (LD50>7000 … Continue reading UDC 615.011:547.857.4 PHARMACOLOGICAL SCREENING OF 3-SUCCINYLSUBSTITUTED N-PHENYLANTHRANILIC ACIDS М.М.Suleyman, S.G.Isaev, А.M.Semenov, T.S.Sakharova, M.V.Zupanets

UDC 615.33:616.34 EXPERIMENTAL MODELING OF INTESTINAL DYSBIOSIS INDUCED BY DICLOFENAC SODIUM IN GUINEAN PIGS AND THE INFLUENCE OF BIFIDUMBACTERIN ON FUNCTIONAL CHARACTERISTICS OF THE INTESTINE IN THE REPRODUCIBLE CONDITIONS N.I.Filimonova, V.O.Pasisnychenko, Mohamed Moftah Elati, S.V.Misyureva

The aim of the research was to develop an experimental model of intestinal dysbiosis induced by diclofenac sodium and to study the effect of probiotic Bifidumbacterin on functional characteristics of the intestine in the reproducible conditions. Animals were divided into 2 groups of 10 animals in each group. The group of control pathology received daily … Continue reading UDC 615.33:616.34 EXPERIMENTAL MODELING OF INTESTINAL DYSBIOSIS INDUCED BY DICLOFENAC SODIUM IN GUINEAN PIGS AND THE INFLUENCE OF BIFIDUMBACTERIN ON FUNCTIONAL CHARACTERISTICS OF THE INTESTINE IN THE REPRODUCIBLE CONDITIONS N.I.Filimonova, V.O.Pasisnychenko, Mohamed Moftah Elati, S.V.Misyureva

UDC 615.282:615.322:582.972.3 THE ANTIFUNGAL ACTIVITY OF LIPOPHILIC FACTIONS OF GALIUM SPECIES. Message 2 N.V.Kashpur, O.V.Goryacha, T.V.Ilyina, A.M.Kovalyova, A.Yu.Volyansky, T.P.Osolodchenko

The antifungal activity of ethylacetate-ethanolic (8:2) fractions of Lady’s Bedstraw (Galium verum L.), Galium salicifolium Klok. and Cruciform Bedstraw (Galium cruciata (L.) Scop.) with respect to 10 test strains of Candida fungi: C. albicans ATCC 885/653, C. parapsilosis 488/10, С. yamata (Debariomyces hansenii) 40 b / 3 C. rugosa Sklyar 27, C. tropicalis F-195, C. … Continue reading UDC 615.282:615.322:582.972.3 THE ANTIFUNGAL ACTIVITY OF LIPOPHILIC FACTIONS OF GALIUM SPECIES. Message 2 N.V.Kashpur, O.V.Goryacha, T.V.Ilyina, A.M.Kovalyova, A.Yu.Volyansky, T.P.Osolodchenko

UDC 615.451.1.015: 616 — 001.12 THE STUDY OF “BIOFLORIN” OINTMENT EFFECTIVENESS ON THE MODEL OF THE BURN INJURY IN RATS L.V.Yakovleva, O.V.Tkachova, O.M.Gorban

On the model of burn trauma of degree II in rats the effectiveness of “Bioflorin” ointment containing a thick oak bark extract and the essential oil of coriander has been studied. The known reparative ointment of the natural origin “Algofin” used in medical practice for the local treatment of skin burns at the II and … Continue reading UDC 615.451.1.015: 616 — 001.12 THE STUDY OF “BIOFLORIN” OINTMENT EFFECTIVENESS ON THE MODEL OF THE BURN INJURY IN RATS L.V.Yakovleva, O.V.Tkachova, O.M.Gorban